VaxArray® for Pneumococcal Vaccines

Simultaneously Measure Up To 23 Pneumococcal Polysaccharide Serotypes

Ready-to-Use Test Kit for Multiplexed Identity, Quantity, and Stability

At the heart of the VaxArray Pneumococcal Assay Kit are simple microarrays, each of which contains 23 serotype-specific monoclonal antibodies for high priority pneumococcal capsular polysaccharide serotypes present in a variety of both on-market and in-development pneumococcal vaccines. With the ability to characterize all 23 represented serotypes in both pneumococcal conjugate and pneumococcal polysaccharide vaccine samples in less than 30 minutes, the test offers substantial time, throughput, and labor savings over the singleplex technologies.

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Benefits

  • Fast multiplex assay, <30 minutes for simultaneous quantification of up to 23 high priority serotypes
  • Perform identity, quantity, or stability testing for both pneumococcal conjugate and pneumococcal polysaccharide vaccine samples
  • Eliminate the requirement to bridge different analytical techniques between drug substance and drug product by using one assay throughout manufacturing, release, and stability testing
  • Standardize with off-the-shelf kits consisting of high-quality mAb for the following serotypes: 1, 2, 3, 4, 5, 6A, 6B, 7F, 8, 9N, 9V, 10A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F, 33F
  • High specificity and sensitivity with large dynamic range from low ng/mL to low µg/mL

Applications

One assay applicable throughout manufacturing, release, and stability testing:

  • Confirm identity after polysaccharide and conjugate purification
  • Verify serotype presence and identity quickly and efficiently after shipment and receipt at alternative site
  • Quantify polysaccharides and conjugates in monovalent and multivalent samples
  • Monitor stability by measuring increase in free polysaccharide over time
  • Measure change in degree of adjuvant adsorption over time
  • Directly measure conjugate concentration via unique CRM197 labeling method

Relevant Resources

Other Services

Pneumococcal Vaccine Testing Services

Prefer InDevR to run your samples?  Inquire about our standard testing services using this kit.

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VaxArray Custom Kits

InDevR can develop a custom kit that improves your vaccine development or serological testing needs.

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