Subtype Specific Influenza Vaccine Quantification
Hemagglutinin, neuraminidase, or nucleoprotein quantification at any manufacturing process step or from cell-based mRNA expression.
Quantitative, stability indicating measurements of vaccines can be difficult, time consuming, and inaccurate. VaxArray solves these issues by providing a rapid, multiplexed measure of influenza protein concentration using an immunoassay built into a microarray format. Specifically designed for analysis of seasonal and pandemic flu vaccines, VaxArray allows for simultaneous analysis of quadrivalent vaccine formulations even in crude, upstream matrices.
VaxArray is compatible with different therapeutic modalities including egg- and cell-based vaccine production methods as well as mRNA in vivo expression. The flexibility and expediency of mRNA vaccine technology has resulted in an industry focus to address influenza due to its seasonal strain fluctuations. Monovalent mRNA construct development and multiplexed LNP product assessments can be further accelerated through quantification of mRNA-driven protein expression in relevant human cell lines.
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